A recent study was conducted by Neil Sachandani, BS and associates of the Washington University School of Medicine in St. Louis. It was to assess the effectiveness of budesonide for the treatment of chronic rhinosinusitis. Furthermore, they also determined the effects of the steroid in the adrenal function. Suppression of the adrenal glands could lead to absorption of the drug throughout the whole body, which is a known complication.

Budesonide is a corticosteroid used for the treatment of asthma, nasal polyps, hay fever, and sinusitis. It is also used additionally for the treatment of Crohn’s disease.

Researchers prepared a solution containing 0.25 mg budesonide and 5 ml saline. The participants were then instructed to apply the solution in each nostril for 30 days. The participants were also made to fill up questionnaires regarding the symptoms of their condition as well as the related quality of life. This was done twice during the whole period of the study, before administering the treatment and at the end of the treatment period.

All participants reported some forms of improvement in their condition after budesonide therapy. Furthermore, adrenal functions among participants were noted to remain normal. Sixty-seven percent of the respondents even said that they would recommend this method of treatment to their family and friends.

From Eurekalert:

A nasal wash containing the corticosteroid budesonide appears to reduce symptoms of chronic rhinosinusitis without suppressing the function of the adrenal glands, a known complication of this type of drug that would indicate absorption throughout the whole body, according to a report in the March issue of Archives of Otolaryngology–Head & Neck Surgery, one of the JAMA/Archives journals.

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