Pharmacists can considerably reduce worries of patients in relation to the use of steroids by as much as 50 percent through intervening to address patients’ concerns, as per a new research launched at the British Pharmaceutical Conference in Manchester.

The study, which was undertaken by Pharmacy Alliance, the Medicines Management Division of UniChem, investigated the inputs of community pharmacists in collaboration with general physicians for meeting the needs of patients with atomic eczema.

From News-Medical.Net:

The results showed that, following help and advice from a pharmacist, or pharmacy staff:

* Steroid concerns reduced from 68% to 30%

* Poor understanding of atopic eczema fell from 43% to 6%

* The need for lifestyle advice dropped from 51% to 20%

The research also found that:

Community pharmacists identified a total of 1,597 problems. Of these:

* 20% involved steroid concerns

* 15% required lifestyle advice

* 12% of patients had unmet treatment goals

* 11% of patients had poor understanding of atopic eczema

Pharmacist Caroline Tinkler who led the study remarked that it is important for the patients to be appropriately educated about eczema and treatment to derive optimum benefits and relief.

It was suggested that a pharmacist advice can relieve worries of patients who are about to use topical corticosteroids, to a great extent.

A new discovery by scientists at the University of Edinburgh as part of a study that was published in Nature Medicine journal, patients struggling with inflammatory conditions such as chronic diseases of the lung, joints and other organs can now expect great relief.

This study suggested how certain drugs, already tested as cancer treatment options may reduce the level of tissue inflammation.

From News-Medical.Net:

Professor Chris Haslett, Head of the Queen’s Medical Research Institute at the University of Edinburgh, expects the study to lead to trials of these drugs in human inflammatory diseases. Professors Adriano Rossi and Haslett, who have led this new study with other colleagues from the QMRI, said: “This study offers new hope for patients with severe inflammatory diseases. Specific treatment for such conditions is poor, and the use of steroids is fraught with potential difficulties. We have adopted a different strategy by using non-biological treatments, but this study needs urgently to be translated into trials and we are now seeking major funding to research further how these drugs work.”

It is worthwhile to note here that lab tests have highlighted the fact that CDK inhibitors, like Roscovitine, can significantly minimize the inflammation level in models of rheumatoid arthritis and the fatal ailment called fibrosing alveolitis.

Estrogen can stop the damage caused by stroke by inactivating P53, a tumor-suppressing protein, which is known for preventing many cancer forms, according to Medical College of Georgia researchers.

Limor Raz, a fourth-year Ph.D. student in the MCG School of Graduate Studies, said that this research clearly suggests that estrogen surpasses P53 after a stroke for curbing the damage.

From News-Medical.Net:

P53, the protein in the mitochondria, or powerhouse, of the cell, is known as “the guardian of the genome” because it regulates the cell cycle and prevents genome mutation. It also can prevent cancer by suppressing tumor growth.

It is known that stressful conditions such as a stroke activate p53, triggering unfavorable changes in the cell. One change is the activation of another protein called PUMA, which signals a cascading effect that destroys the mitochondria and causes cell death, or apoptosis.

Ms. Raz further said that estrogen has the potential to alter p53 chemically besides attenuating the cascade to result in minimized stroke damage.

Raz has been working with Dr. Darrell Brann, chief of developmental neurobiology and associate director of the MCG Institute of Molecular Medicine and Genetics and presented her findings at the American Physiological Society conference aimed at the cardiovascular effects of sex steroids and gender.

According to researchers from the German Sport University Cologne in Germany, non-steroidal and tissue-selective anabolic agents like Selective Androgen Receptor Modulators (SARMs) are being openly sold on the black market due to their performance enhancing properties.

The finding was revealed after detection of the drug candidate Andarine in a product sold via the Internet, which one again highlighted the fact that availability of authentic SARMs draws people to them.

From Sciencedaily.com:

In 2008, the World Anti-Doping Agency (WADA) prohibited the use of SARMs in sports due to their potential for misuse. WADA closely cooperates with pharmaceutical and biotechnological companies, as well as medicine agencies and drug evaluation bodies on the issue of therapeutics being misused in sports. WADA’s preventive approach was validated with the recent finding of a commercially available, non-approved arylpropionamide-derived SARM termed Andarine. This product, declared as green tea extracts and face moisturizer to pass customs, was available on the Internet at a discount price of $100 USD.

To prove that SARMs lacking clinical approval are distributed and potentially misused in sports, Mario Thevis, Ph.D., and colleagues, analyzed the advertised substance using state-of-the-art mass spectrometric approaches with high resolution/high accuracy (tandem) mass spectrometry. “One unit (30 mL) was purchased online and delivered in a box labeled to contain face moisturizer and green tea extract. The sealed bottle did not declare any content and no further documents accompanied package,” said Dr. Thevis.

Mario Thevis, Ph.D., and colleagues, said that SARMs coming with significant anabolic properties are nowadays easily available without sufficient research on their undesirable effects.

This matter was recently addressed at the Conference of Parties to the International Convention against Doping in Sport, held October 26-28, 2009 at the United Nations Educational, Scientific and Cultural Organization’s (UNESCO) headquarters in Paris.

A peer-led and sport team-centered program can help in reducing eating disordered behavior and body-shaping drug use in female high school athletes, according to an article in issue of The Archives of Pediatrics & Adolescent Medicine.

The article revealed that about half of high school students (male and female) participate in school sports and the pressure to win often influence young women to come in close proximity to disordered eating behaviors, drug use (tobacco, diet pills, diuretics, laxatives, amphetamines, and anabolic steroids).

From News-Medical.Net:

The researchers found that athletes participating in the ATHENA program reported significantly less ongoing and new use of diet pills, and less use of amphetamines, anabolic steroids, and sport supplements. These athletes also reported more seatbelt use and less new sexual activity. The ATHENA athletes also had positive changes in healthy eating behaviors, and reductions in intent to use diet pills in the future, vomiting to lose weight and tobacco use.

“The ATHENA curriculum succeeded in most of its prevention and health promotion goals,” the authors write. “Following their sport season, intervention students reported less ongoing and new diet pill use and less new use of athletic-enhancing, body-shaping substances (amphetamines, anabolic steroids, and muscle-building supplements). Experimental participants understood more about the presented topics, had improved self-reported dietary habits, and indicated greater self-efficacy for exercise training,” write the researchers.

The topics in the ATHENA program were gender specific and consisted of information on effective exercise training, drug use, depression prevention, media images of women, and healthy sport nutrition.

According to a new study, nitric oxide level in an asthmatic patient’s exhaled breath can portend worsening of asthma symptoms to some extent along with signifying an imminent attack linked to underlying airway inflammation.

These facts have raised the interest of clinicians apart from providing a potential breakthrough for formulating medications and enhance the results of treatment methodologies when it comes to monitoring nitric oxide levels.

From Sciencedaily.com:

Still, in light of these findings, it is clear that FENO monitoring should only be applied to those who stand to gain the most. “There can be no doubt that adding frequent assessments of FENO to management plans of most children and adults with asthma will add unjustifiable costs without providing clinical benefit. Whether there is a role for monitoring FENO to aid management of severe asthma is untested,” wrote Stephen Stick, Ph.D., of the Princess Margaret Hospital for Children in Perth, Australia and Peter Franklin, Ph.D., of the Centre for Asthma, Allergy and Respiratory Research at the University of Western Australia in Perth in an editorial that accompanied the article.

“We did not address other possible applications of frequent FENO monitoring, such as prediction of steroid effect. Loss of control, prediction and prevention of exacerbations, and tapering of steroids in symptom-free children who wheezed in the past,” noted Dr. de Jongste. “We think there is good reason to study these potential applications.”

It was remarked by Johan C. de Jongste, M.D., Ph.D., at the Erasmus University Medical Center-Sophia Children’s Hospital in the Netherlands, and colleagues, that there is more than just a reason to go further to study about these potential applications in the near future.

More and more sportsmen are using anabolic steroids these days to gain a competitive edge and stay ahead of the peers, as evident from the growing number of sportsmen opting for anabolic steroids on the Internet.

However, what many people forget is the fact that steroids do not pose any harm to the users if used under medical advice and help sportsmen delivers dramatic performance on a continuing basis.

From Entertainment.howstuffworks.com:

Anabolic Steroids

A steroid is a chemical substance derived from cholesterol. The body has several major steroid hormones — cortisol and testosterone in the male, estrogen and progesterone in the female. Catabolic steroids break down tissue, and anabolic steroids build up tissue. Anabolic steroids build muscle and bone mass primarily by stimulating the muscle and bone cells to make new protein.

Athletes use anabolic steroids because they increase muscle strength by encouraging new muscle growth. Anabolic steroids are similar in structure to the male sex hormone, testosterone, so they enhance male reproductive and secondary sex characteristics (testicle development, hair growth, thickening of the vocal cords). They allow the athlete to train harder and longer at any given period.

Anabolic steroids are mostly testosterone (male sex hormone) and its derivatives. Examples of anabolic steroids include:

* Testosterone

* Dihydrotestosterone

* Androstenedione (Andro)

* Dehydroepiandrosterone (DHEA)

* Clostebol

* Nandrolone

It is, however, of great mention that steroid abuse and sub-standard steroids can result in side effects and must be avoided at all stages.